A representative from HMV was so impressed by her singing talent that he made her sing a Qawwali, which became very popular. Her elder sister, Gauherbai, was an actress and helped Amirbai get a role in the film Vishnu Bhakti in 1934. Initially, Amirbai sang songs in films, but they failed to attain the success she desired. In 1943, with the release of Bombay Talkies' Kismet (1943 film) (1943), she achieved popularity: the songs of Kismet became a rage and Amirbai became famous. The man behind the success was the composer Anil Biswas. She was initially known as a singing star, but at the decline of her career she became a playback singer. She reached her peak by 1947.
She was married Badri Kaanchwala, the editor of Paras. At this time Lata Mangeshkar became a rising star, so once again Amirbai switched over to acting. In her later years she mostly played character roles. Amirbai also composed music for Wahab Pictures' Shehnaaz (1948). In the same year she almost left Hindi Cinema for Gujarati and Marwari films. She had a paralytic attack in 1965, died just four days later and was buried in her hometown. A cinema hall still runs in the name of 'Amir Talkies' in the city of Bijapur by her family.